Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
Blog Article
Drug interactions: Most stories of clinically major drug interactions taking place with the barbiturates have associated phenobarbital.
pentobarbital will reduce the level or effect of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will reduce the level or effect of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
four. Compatible with Dying in aged or unwell individuals or in presence of obstructed airway, other poisonous agents, or publicity to cold.
pentobarbital will lessen the level or effect of avanafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. For people with ED, observe response cautiously due to potential for decreased effectiveness.
In primates, publicity to 3 several hours of ketamine that created a light-weight surgical plane of anesthesia did not boost neuronal mobile decline, however, therapy regimens of 5 several hours or for a longer time of isoflurane elevated neuronal cell reduction. Data from isoflurane-dealt with rodents and ketamine-addressed primates recommend that the neuronal and oligodendrocyte mobile losses are affiliated with prolonged cognitive deficits in learning and memory. The scientific significance of such nonclinical results just isn't recognized, and healthcare suppliers should stability the key benefits of appropriate anesthesia in pregnant Women of all ages, neonates, and young children who need methods with the potential challenges prompt through the nonclinical info (see “Warnings-Pediatric Neurotoxicity”, “Safeguards-Pregnancy”, and “Animal Pharmacology and/or Toxicology”.)
pentobarbital will minimize the level or effect of triamcinolone acetonide injectable suspension by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Elderly individuals may perhaps respond to barbiturates with marked pleasure, melancholy, and confusion. In a few people, barbiturates consistently make excitement as opposed to depression. Dosage really should be reduced during the aged since these patients might be additional delicate read more to barbiturates.
fentanyl iontophoretic transdermal method and pentobarbital each increase sedation. Steer clear of or Use Alternate Drug. Restrict use to individuals for whom alternative treatment method alternatives are insufficient
pentobarbital will reduce the level or effect of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
pentobarbital will reduce the extent or effect of etonogestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will boost the level or effect of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers decreased ivosidenib plasma concentrations.
pentobarbital will minimize the level or effect of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name previously used: bishydroxycoumarin) and causes a minimize in anticoagulant action as measured by the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to elevated metabolism and lessened anticoagulant response of oral anticoagulants (e.